Virus-specific activation of a novel interferon regulatory factor, IRF-5, results in the induction of distinct interferon α genes
BJ Barnes, PA Moore, PM Pitha - Journal of Biological Chemistry, 2001 - jbc.org
Interferon regulatory factor (IRF) genes encode DNA-binding proteins that are involved in
the innate immune response to infection. Two of these proteins, IRF-3 and IRF-7, serve as
direct transducers of virus-mediated signaling and play critical roles in the induction of type I
interferon genes. We have now shown that another factor, IRF-5, participates in the induction
of interferon A (IFNA) and IFNB genes and can replace the requirement for IRF-7 in the
induction of IFNA genes. We demonstrate that, despite the functional similarity, IRF-5 …
the innate immune response to infection. Two of these proteins, IRF-3 and IRF-7, serve as
direct transducers of virus-mediated signaling and play critical roles in the induction of type I
interferon genes. We have now shown that another factor, IRF-5, participates in the induction
of interferon A (IFNA) and IFNB genes and can replace the requirement for IRF-7 in the
induction of IFNA genes. We demonstrate that, despite the functional similarity, IRF-5 …
