The IRF family transcription factors in immunity and oncogenesis
T Tamura, H Yanai, D Savitsky… - Annu. Rev. Immunol …, 2008 - annualreviews.org
The interferon regulatory factor (IRF) family, consisting of nine members in mammals, was
identified in the late 1980s in the context of research into the type I interferon system.
Subsequent studies over the past two decades have revealed the versatile and critical
functions performed by this transcription factor family. Indeed, many IRF members play
central roles in the cellular differentiation of hematopoietic cells and in the regulation of gene
expression in response to pathogen-derived danger signals. In particular, the advances …
identified in the late 1980s in the context of research into the type I interferon system.
Subsequent studies over the past two decades have revealed the versatile and critical
functions performed by this transcription factor family. Indeed, many IRF members play
central roles in the cellular differentiation of hematopoietic cells and in the regulation of gene
expression in response to pathogen-derived danger signals. In particular, the advances …
