The hormone leptin regulates fat storage and metabolism by signaling through the brain and
peripheral tissues. Lipids delivered to peripheral tissues originate mostly from the intestine
and liver via synthesis and secretion of apolipoprotein B (apoB)-containing lipoproteins. An
intracellular chaperone, microsomal triglyceride transfer protein (MTP), is required for the
biosynthesis of these lipoproteins, and its regulation determines fat mobilization to different
tissues. Using cell culture and animal models, here we sought to identify the effects of leptin …