The endoplasmic reticulum (ER) lies at the crossroads of protein folding, calcium storage,
lipid metabolism, and the regulation of autophagy and apoptosis. Accordingly, dysregulation
of ER homeostasis leads to β-cell dysfunction in type 1 and type 2 diabetes that ultimately
culminates in cell death. The ER is therefore an emerging target for understanding the
mechanisms of diabetes mellitus that captures the complex etiologies of this multifactorial
class of metabolic disorders. Our strategy for developing ER-targeted diagnostics and …