The formation of focal granular enlargements within axons (axonal spheroids or “torpedoes”;
neuroaxonal dystrophy) is a well known phenomenon occurring in a variety of neurological
diseases. The relative susceptibility of different types of neurons to this kind of axonal
pathology, however, is largely unknown. An immunocytochemical study directed at
localizing glutamic acid decarboxylase (GAD), the synthetic enzyme for the inhibitory
neurotransmitter, γ-aminobutyric acid (GABA), in various CNS regions in feline models of …