Cytokine storms: understanding COVID-19
N Mangalmurti, CA Hunter - Immunity, 2020 - cell.com
Immunity, 2020•cell.com
The elevated circulating levels of cytokines associated with a variety of infectious and
immune-mediated conditions are frequently termed a cytokine storm. Here, we explain the
protective functions of cytokines in" ideal" responses; the multi-factorial origins that can drive
these responses to become pathological; and how this ultimately leads to vascular damage,
immunopathology, and worsening clinical outcomes.
immune-mediated conditions are frequently termed a cytokine storm. Here, we explain the
protective functions of cytokines in" ideal" responses; the multi-factorial origins that can drive
these responses to become pathological; and how this ultimately leads to vascular damage,
immunopathology, and worsening clinical outcomes.
Summary
The elevated circulating levels of cytokines associated with a variety of infectious and immune-mediated conditions are frequently termed a cytokine storm. Here, we explain the protective functions of cytokines in "ideal" responses; the multi-factorial origins that can drive these responses to become pathological; and how this ultimately leads to vascular damage, immunopathology, and worsening clinical outcomes.
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