Correlation between disease severity and in vitro cytokine production mediated by MSRV (multiple sclerosis associated retroviral element) envelope protein in …
A Rolland, E Jouvin-Marche, M Saresella… - Journal of …, 2005 - Elsevier
MSRV is a retroviral element previously isolated in cell cultures from patients with multiple
sclerosis. It is part of a new multi-copy endogenous retrovirus family named HERV-W and
displays pro-inflammatory properties both in vitro in human PBMC cultures and in vivo in a
humanized SCID mice model. In the present study, we have evaluated potential links
between the pro-inflammatory properties of MSRV envelope protein and MS disease. Thus,
cytokine productions mediated by the surface unit of MSRV envelope protein were …
sclerosis. It is part of a new multi-copy endogenous retrovirus family named HERV-W and
displays pro-inflammatory properties both in vitro in human PBMC cultures and in vivo in a
humanized SCID mice model. In the present study, we have evaluated potential links
between the pro-inflammatory properties of MSRV envelope protein and MS disease. Thus,
cytokine productions mediated by the surface unit of MSRV envelope protein were …