PTEN expression in non–small-cell lung cancer: evaluating its relation to tumor characteristics, allelic loss, and epigenetic alteration
The tumor suppressor PTEN encodes a lipid phosphatase that negatively regulates the
phosphatidylinositol 3-kinase/AKT cell survival pathway. Mutations of this gene are common
in brain, prostate, endometrial, and gastric cancers but occur rarely in non–small-cell lung
cancer (NSCLC), although the PTEN protein is often lost in lung tumors. We have studied
hypermethylation of the PTEN promoter, loss of heterozygosity (LOH) at microsatellites in
chromosome 10q23 (surrounding and intragenic to the PTEN locus), and hypermethylation …
phosphatidylinositol 3-kinase/AKT cell survival pathway. Mutations of this gene are common
in brain, prostate, endometrial, and gastric cancers but occur rarely in non–small-cell lung
cancer (NSCLC), although the PTEN protein is often lost in lung tumors. We have studied
hypermethylation of the PTEN promoter, loss of heterozygosity (LOH) at microsatellites in
chromosome 10q23 (surrounding and intragenic to the PTEN locus), and hypermethylation …