A novel conditional mouse model for Nkx2-5 reveals transcriptional regulation of cardiac ion channels
MB Furtado, JC Wilmanns, A Chandran, M Tonta… - Differentiation, 2016 - Elsevier
Nkx2-5 is one of the master regulators of cardiac development, homeostasis and disease.
This transcription factor has been previously associated with a suite of cardiac congenital
malformations and impairment of electrical activity. When disease causative mutations in
transcription factors are considered, NKX2-5 gene dysfunction is the most common
abnormality found in patients. Here we describe a novel mouse model and subsequent
implications of Nkx2-5 loss for aspects of myocardial electrical activity. In this work we have …
This transcription factor has been previously associated with a suite of cardiac congenital
malformations and impairment of electrical activity. When disease causative mutations in
transcription factors are considered, NKX2-5 gene dysfunction is the most common
abnormality found in patients. Here we describe a novel mouse model and subsequent
implications of Nkx2-5 loss for aspects of myocardial electrical activity. In this work we have …