Taspase 1: a protease with many biological surprises
H Niizuma, EH Cheng, JJ Hsieh - Molecular & cellular oncology, 2015 - Taylor & Francis
H Niizuma, EH Cheng, JJ Hsieh
Molecular & cellular oncology, 2015•Taylor & FrancisTaspase 1 (TASP1) cleaves the mixed-lineage leukemia (MLL) and transcription factor (TF)
IIA families of nuclear proteins to orchestrate various biological processes. TASP1 is not a
classical oncogene, but assists in cell proliferation and permits oncogenic initiation through
cleavage of MLL and TFIIA. TASP1 is thus better classified as a “non-oncogene addiction”
protease, and targeting TASP1 offers a novel and attractive anticancer therapeutic strategy.
IIA families of nuclear proteins to orchestrate various biological processes. TASP1 is not a
classical oncogene, but assists in cell proliferation and permits oncogenic initiation through
cleavage of MLL and TFIIA. TASP1 is thus better classified as a “non-oncogene addiction”
protease, and targeting TASP1 offers a novel and attractive anticancer therapeutic strategy.
Taspase 1 (TASP1) cleaves the mixed-lineage leukemia (MLL) and transcription factor (TF) IIA families of nuclear proteins to orchestrate various biological processes. TASP1 is not a classical oncogene, but assists in cell proliferation and permits oncogenic initiation through cleavage of MLL and TFIIA. TASP1 is thus better classified as a “non-oncogene addiction” protease, and targeting TASP1 offers a novel and attractive anticancer therapeutic strategy.
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