[HTML][HTML] FRS2 via fibroblast growth factor receptor 1 is required for platelet-derived growth factor receptor β-mediated regulation of vascular smooth muscle marker …
PY Chen, M Simons, R Friesel - Journal of biological chemistry, 2009 - ASBMB
Vascular smooth muscle cells (VSMC) exhibit phenotypic plasticity and change from a
quiescent contractile phenotype to a proliferative synthetic phenotype during physiological
arteriogenesis and pathological conditions such as atherosclerosis and restenosis. Platelet-
derived growth factor (PDGF)-BB is a potent inducer of the VSMC synthetic phenotype;
however, much less is known about the role of fibroblast growth factor-2 (FGF2) in this
process. Here, we show using signal transduction mutants of FGF receptor 1 (FGFR1) …
quiescent contractile phenotype to a proliferative synthetic phenotype during physiological
arteriogenesis and pathological conditions such as atherosclerosis and restenosis. Platelet-
derived growth factor (PDGF)-BB is a potent inducer of the VSMC synthetic phenotype;
however, much less is known about the role of fibroblast growth factor-2 (FGF2) in this
process. Here, we show using signal transduction mutants of FGF receptor 1 (FGFR1) …