[HTML][HTML] Imatinib treatment attenuates growth and inflammation of angiotensin II induced abdominal aortic aneurysm
E Vorkapic, E Dugic, S Vikingsson, J Roy… - Atherosclerosis, 2016 - Elsevier
Background Abdominal aortic aneurysm (AAA) is characterized by vascular remodeling with
increased infiltration of inflammatory cells and apoptosis/modulation of vascular smooth
muscle cells (SMCs). Imatinib is a selective inhibitor of several tyrosine kinases, including
PDGF receptors, Abl, and c-kit. The objective of this study was to characterize the potential
protective role of imatinib on AAA development and the molecular mechanisms involved.
Methods Male ApoE−/− mice were infused with angiotensin (Ang) II (1000 ng/kg/min) for 4 …
increased infiltration of inflammatory cells and apoptosis/modulation of vascular smooth
muscle cells (SMCs). Imatinib is a selective inhibitor of several tyrosine kinases, including
PDGF receptors, Abl, and c-kit. The objective of this study was to characterize the potential
protective role of imatinib on AAA development and the molecular mechanisms involved.
Methods Male ApoE−/− mice were infused with angiotensin (Ang) II (1000 ng/kg/min) for 4 …