[HTML][HTML] Macrophage diversity in renal injury and repair

SD Ricardo, H Van Goor, AA Eddy - The Journal of clinical …, 2008 - Am Soc Clin Investig
The Journal of clinical investigation, 2008Am Soc Clin Investig
Monocyte-derived macrophages can determine the outcome of the immune response and
whether this response contributes to tissue repair or mediates tissue destruction. In addition
to their important role in immune-mediated renal disease and host defense, macrophages
play a fundamental role in tissue remodeling during embryonic development, acquired
kidney disease, and renal allograft responses. This review summarizes macrophage
phenotype and function in the orchestration of kidney repair and replacement of specialized …
Monocyte-derived macrophages can determine the outcome of the immune response and whether this response contributes to tissue repair or mediates tissue destruction. In addition to their important role in immune-mediated renal disease and host defense, macrophages play a fundamental role in tissue remodeling during embryonic development, acquired kidney disease, and renal allograft responses. This review summarizes macrophage phenotype and function in the orchestration of kidney repair and replacement of specialized renal cells following injury. Recent advances in our understanding of macrophage heterogeneity in response to their microenvironment raise new and exciting therapeutic possibilities to attenuate or conceivably reverse progressive renal disease in the context of fibrosis. Furthermore, parallels with pathological processes in many other organs also exist.
The Journal of Clinical Investigation