KLF4 in macrophages attenuates TNFα-mediated kidney injury and fibrosis
Background Polarized macrophage populations can orchestrate both inflammation of the
kidney and tissue repair during CKD. Proinflammatory M1 macrophages initiate kidney
injury, but mechanisms through which persistent M1-dependent kidney damage culminates
in fibrosis require elucidation. Krüppel-like factor 4 (KLF4), a zinc-finger transcription factor
that suppresses inflammatory signals, is an essential regulator of macrophage polarization
in adipose tissues, but the effect of myeloid KLF4 on CKD progression is unknown. Methods …
kidney and tissue repair during CKD. Proinflammatory M1 macrophages initiate kidney
injury, but mechanisms through which persistent M1-dependent kidney damage culminates
in fibrosis require elucidation. Krüppel-like factor 4 (KLF4), a zinc-finger transcription factor
that suppresses inflammatory signals, is an essential regulator of macrophage polarization
in adipose tissues, but the effect of myeloid KLF4 on CKD progression is unknown. Methods …