CD103+ dendritic cells elicit CD8+ T cell responses to accelerate kidney injury in adriamycin nephropathy
Q Cao, J Lu, Q Li, C Wang, XM Wang… - Journal of the …, 2016 - journals.lww.com
Abstract CD103+ dendritic cells (DCs) in nonlymphoid organs exhibit two main functions:
maintaining tolerance by induction of regulatory T cells and protecting against tissue
infection through cross-presentation of foreign antigens to CD8+ T cells. However, the role of
CD103+ DCs in kidney disease is unknown. In this study, we show that CD103+ DCs are
one of four subpopulations of renal mononuclear phagocytes in normal kidneys. CD103+
DCs expressed DC-specific surface markers, transcription factors, and growth factor …
maintaining tolerance by induction of regulatory T cells and protecting against tissue
infection through cross-presentation of foreign antigens to CD8+ T cells. However, the role of
CD103+ DCs in kidney disease is unknown. In this study, we show that CD103+ DCs are
one of four subpopulations of renal mononuclear phagocytes in normal kidneys. CD103+
DCs expressed DC-specific surface markers, transcription factors, and growth factor …