[HTML][HTML] The transcription factor Twist1 limits T helper 17 and T follicular helper cell development by repressing the gene encoding the interleukin-6 receptor α chain
Cytokine responsiveness is a critical component of the ability of cells to respond to the
extracellular milieu. Transcription factor-mediated regulation of cytokine receptor expression
is a common mode of altering responses to the external environment. We identify the
transcription factor Twist1 as a component of a STAT3-induced feedback loop that controls
IL-6 signals by directly repressing Il6ra. Human and mouse T cells lacking Twist1 have an
increased ability to differentiate into Th17 cells. Mice with a T cell-specific deletion of Twist1 …
extracellular milieu. Transcription factor-mediated regulation of cytokine receptor expression
is a common mode of altering responses to the external environment. We identify the
transcription factor Twist1 as a component of a STAT3-induced feedback loop that controls
IL-6 signals by directly repressing Il6ra. Human and mouse T cells lacking Twist1 have an
increased ability to differentiate into Th17 cells. Mice with a T cell-specific deletion of Twist1 …