TLR4 links podocytes with the innate immune system to mediate glomerular injury

MC Banas, B Banas, KL Hudkins… - Journal of the …, 2008 - journals.lww.com
Toll-like receptors (TLR) classically recognize pathogen-associated danger signals but are
also activated via endogenous ligands. For evaluation of their role in inflammatory kidney
disease, the function of TLR was analyzed in two mouse models of cryoglobulinemic
membranoproliferative glomerulonephritis (MPGN; mice transgenic for thymic stromal
lymphopoietin [TSLP], with or without deletion of the Fcγ receptor IIb). Expression of TLR1
through 9 and TLR11 mRNA was detectable in whole kidneys and in isolated glomeruli of …