Grass pollen immunotherapy: IL-10 induction and suppression of late responses precedes IgG4 inhibitory antibody activity
JN Francis, LK James, G Paraskevopoulos… - Journal of Allergy and …, 2008 - Elsevier
BACKGROUND: Grass pollen immunotherapy is an effective treatment for seasonal allergic
rhinitis that provides the opportunity to study the induction and maintenance of allergen-
specific immune tolerance. OBJECTIVES: We investigated the relationship between clinical
responsiveness, regulatory cytokine production, and antibody responses to allergen during
1 year of immunotherapy. METHODS: Eighteen subjects with severe seasonal allergic
rhinitis were randomized double-blind to receive active or placebo injections of an alum …
rhinitis that provides the opportunity to study the induction and maintenance of allergen-
specific immune tolerance. OBJECTIVES: We investigated the relationship between clinical
responsiveness, regulatory cytokine production, and antibody responses to allergen during
1 year of immunotherapy. METHODS: Eighteen subjects with severe seasonal allergic
rhinitis were randomized double-blind to receive active or placebo injections of an alum …