Liver sinusoidal endothelial cells (LSECs) are highly specialized endothelial cells
representing the interface between blood cells on the one side and hepatocytes and hepatic
stellate cells on the other side. LSECs represent a permeable barrier. Indeed, the
association of 'fenestrae', absence of diaphragm and lack of basement membrane make
them the most permeable endothelial cells of the mammalian body. They also have the
highest endocytosis capacity of human cells. In physiological conditions, LSECs regulate …