[HTML][HTML] The endothelial lectin clearance receptor CLEC4M binds and internalizes factor VIII in a VWF‐dependent and independent manner
LL Swystun, C Notley, I Georgescu, JD Lai… - Journal of Thrombosis …, 2019 - Elsevier
Essentials• CLEC4M is an endocytic receptor for factor FVIII.• CLEC4M interacts with FVIII in
a VWF‐dependent and independent manner.• CLEC4M binds to mannose‐containing
glycans on FVIII.• CLEC4M internalization of FVIII involves clathrin coated pits. Summary
Background von Willebrand factor (VWF) and factor VIII (FVIII) circulate in the plasma as a
non‐covalent complex, and the majority of FVIII is likely to be cleared by VWF‐dependent
pathways. Clearance of VWF‐free FVIII is rapid and underlies the pathological basis of some …
a VWF‐dependent and independent manner.• CLEC4M binds to mannose‐containing
glycans on FVIII.• CLEC4M internalization of FVIII involves clathrin coated pits. Summary
Background von Willebrand factor (VWF) and factor VIII (FVIII) circulate in the plasma as a
non‐covalent complex, and the majority of FVIII is likely to be cleared by VWF‐dependent
pathways. Clearance of VWF‐free FVIII is rapid and underlies the pathological basis of some …