Mammalian target of rapamycin (mTOR) is a kinase that plays a key role in a wide array of
cellular processes and exists in two distinct functional complexes, mTOR complex 1
(mTORC1) and mTOR complex 2 (mTORC2). Although mTORC2 is primarily activated by
growth factors, mTORC1 is regulated by numerous extracellular and intracellular signals
such as nutrients, growth factors, and cellular redox. Previous study has shown that cysteine
oxidants sufficiently activate mTORC1 activity under amino acid-depleted conditions and …