[HTML][HTML] Redox regulation of the nutrient-sensitive raptor-mTOR pathway and complex
DD Sarbassov, DM Sabatini - Journal of Biological Chemistry, 2005 - ASBMB
The raptor-mTOR protein complex is a key component of a nutrient-sensitive signaling
pathway that regulates cell size by controlling the accumulation of cellular mass. How
nutrients regulate signaling through the raptor-mTOR complex is not well known. Here we
show that a redox-sensitive mechanism regulates the phosphorylation of the raptor-mTOR
effector S6K1, the interaction between raptor and mTOR, and the kinase activity of the raptor-
mTOR complex. In cells treated with the oxidizing agents diamide or phenylarsine oxide …
pathway that regulates cell size by controlling the accumulation of cellular mass. How
nutrients regulate signaling through the raptor-mTOR complex is not well known. Here we
show that a redox-sensitive mechanism regulates the phosphorylation of the raptor-mTOR
effector S6K1, the interaction between raptor and mTOR, and the kinase activity of the raptor-
mTOR complex. In cells treated with the oxidizing agents diamide or phenylarsine oxide …