Mammalian target of rapamycin inhibition with rapamycin mitigates radiation-induced pulmonary fibrosis in a murine model
EJ Chung, A Sowers, A Thetford… - International Journal of …, 2016 - Elsevier
Purpose Radiation-induced pulmonary fibrosis (RIPF) is a late toxicity of therapeutic
radiation. Signaling of the mammalian target of rapamycin drives several processes
implicated in RIPF, including inflammatory cytokine production, fibroblast proliferation, and
epithelial senescence. We sought to determine if mammalian target of rapamycin inhibition
with rapamycin would mitigate RIPF. Methods and Materials C57BL/6NCr mice received a
diet formulated with rapamycin (14 mg/kg food) or a control diet 2 days before and …
radiation. Signaling of the mammalian target of rapamycin drives several processes
implicated in RIPF, including inflammatory cytokine production, fibroblast proliferation, and
epithelial senescence. We sought to determine if mammalian target of rapamycin inhibition
with rapamycin would mitigate RIPF. Methods and Materials C57BL/6NCr mice received a
diet formulated with rapamycin (14 mg/kg food) or a control diet 2 days before and …