Secretory phospholipase A2-mediated depletion of phosphatidylglycerol in early acute respiratory distress syndrome
DL Long, RD Hite, BL Grier, BN Suckling… - The American journal of …, 2012 - Elsevier
Abstract Introduction Secretory phospholipases A 2 (sPLA 2) hydrolyze phospholipids in cell
membranes and extracellular structures such as pulmonary surfactant. This study tests the
hypothesis that sPLA 2 are elevated in human lungs during acute respiratory distress
syndrome (ARDS) and that sPLA 2 levels are associated with surfactant injury by hydrolysis
of surfactant phospholipids. Methods Bronchoalveolar lavage (BAL) fluid was obtained from
18 patients with early ARDS (< 72 hours) and compared with samples from 10 healthy …
membranes and extracellular structures such as pulmonary surfactant. This study tests the
hypothesis that sPLA 2 are elevated in human lungs during acute respiratory distress
syndrome (ARDS) and that sPLA 2 levels are associated with surfactant injury by hydrolysis
of surfactant phospholipids. Methods Bronchoalveolar lavage (BAL) fluid was obtained from
18 patients with early ARDS (< 72 hours) and compared with samples from 10 healthy …