[HTML][HTML] Hydrogen peroxide activates p70S6k signaling pathway
GU Bae, DW Seo, HK Kwon, HY Lee, S Hong… - Journal of Biological …, 1999 - ASBMB
We investigated a possible role of reactive oxygen species (ROS) in p70 S6k activation,
which plays an important role in the progression of cells from G 0/G 1 to S phase of the cell
cycle by translational up-regulation of a family of mRNA transcripts that encode for
components of the protein synthetic machinery. Treatment of mouse epidermal cell JB6 with
H 2 O 2 generated extracellularly by glucose/glucose oxidase led to the activation of p70
S6k and p90 Rsk and to phosphorylation of p42 MAPK/p44 MAPK. The activation of p70 S6k …
which plays an important role in the progression of cells from G 0/G 1 to S phase of the cell
cycle by translational up-regulation of a family of mRNA transcripts that encode for
components of the protein synthetic machinery. Treatment of mouse epidermal cell JB6 with
H 2 O 2 generated extracellularly by glucose/glucose oxidase led to the activation of p70
S6k and p90 Rsk and to phosphorylation of p42 MAPK/p44 MAPK. The activation of p70 S6k …