Translational control during endoplasmic reticulum stress beyond phosphorylation of the translation initiation factor eIF2α
BJ Guan, D Krokowski, M Majumder… - Journal of Biological …, 2014 - jbc.org
The accumulation of unfolded/misfolded proteins in the endoplasmic reticulum (ER) causes
stress to which an unfolded protein response is activated to render cell survival or apoptosis
(chronic stress). Transcriptional and translational reprogramming is tightly regulated during
the unfolded protein response to ensure specific gene expression. The master regulator of
this response is the PERK/eIF2α/ATF4 signaling where eIF2α is phosphorylated (eIF2α-P)
by the kinase PERK. This signal leads to global translational shutdown, but it also enables …
stress to which an unfolded protein response is activated to render cell survival or apoptosis
(chronic stress). Transcriptional and translational reprogramming is tightly regulated during
the unfolded protein response to ensure specific gene expression. The master regulator of
this response is the PERK/eIF2α/ATF4 signaling where eIF2α is phosphorylated (eIF2α-P)
by the kinase PERK. This signal leads to global translational shutdown, but it also enables …
