Ras homolog family member A/Rho-associated protein kinase 1 signaling modulates lineage commitment of mesenchymal stem cells in asthmatic patients through …
X Ke, DC Do, C Li, Y Zhao, M Kollarik, Q Fu… - Journal of Allergy and …, 2019 - Elsevier
Background Numbers of mesenchymal stem cells (MSCs) are increased in the airways after
allergen challenge. Ras homolog family member A (RhoA)/Rho-associated protein kinase 1
(ROCK) signaling is critical in determining the lineage fate of MSCs in tissue
repair/remodeling. Objectives We sought to investigate the role of RhoA/ROCK signaling in
lineage commitment of MSCs during allergen-induced airway remodeling and delineate the
underlying mechanisms. Methods Active RhoA expression in lung tissues of asthmatic …
allergen challenge. Ras homolog family member A (RhoA)/Rho-associated protein kinase 1
(ROCK) signaling is critical in determining the lineage fate of MSCs in tissue
repair/remodeling. Objectives We sought to investigate the role of RhoA/ROCK signaling in
lineage commitment of MSCs during allergen-induced airway remodeling and delineate the
underlying mechanisms. Methods Active RhoA expression in lung tissues of asthmatic …
