[HTML][HTML] The microRNA-130/301 family controls vasoconstriction in pulmonary hypertension
Pulmonary hypertension (PH) is a complex disorder, spanning several known vascular cell
types. Recently, we identified the microRNA-130/301 (miR-130/301) family as a regulator of
multiple pro-proliferative pathways in PH, but the true breadth of influence of the miR-
130/301 family across cell types in PH may be even more extensive. Here, we employed
targeted network theory to identify additional pathogenic pathways regulated by miR-
130/301, including those involving vasomotor tone. Guided by these predictions, we …
types. Recently, we identified the microRNA-130/301 (miR-130/301) family as a regulator of
multiple pro-proliferative pathways in PH, but the true breadth of influence of the miR-
130/301 family across cell types in PH may be even more extensive. Here, we employed
targeted network theory to identify additional pathogenic pathways regulated by miR-
130/301, including those involving vasomotor tone. Guided by these predictions, we …