[HTML][HTML] Peroxisome proliferator-activated receptor-α-mediated transcription of miR-199a2 attenuates endothelin-1 expression via hypoxia-inducible factor-1α
C Li, MSEM Mpollo, CS Gonsalves, SM Tahara… - Journal of Biological …, 2014 - ASBMB
Endothelin-1, a potent vasoconstrictor, plays an important role in pulmonary hypertension
(PH) in sickle cell disease (SCD). Our previous studies show that higher levels of placenta
growth factor (PlGF), secreted by erythroid precursor cells, correlate with increased plasma
levels of endothelin-1 (ET-1) and other functional markers of PH in SCD. PlGF-mediated ET-
1 expression occurs via activation of hypoxia-inducible factor-1α (HIF-1α). However,
relatively less is understood regarding how PlGF-mediated expression of HIF-1α and its …
(PH) in sickle cell disease (SCD). Our previous studies show that higher levels of placenta
growth factor (PlGF), secreted by erythroid precursor cells, correlate with increased plasma
levels of endothelin-1 (ET-1) and other functional markers of PH in SCD. PlGF-mediated ET-
1 expression occurs via activation of hypoxia-inducible factor-1α (HIF-1α). However,
relatively less is understood regarding how PlGF-mediated expression of HIF-1α and its …