PPARγ and the pathobiology of pulmonary arterial hypertension
M Rabinovitch - Membrane receptors, channels and transporters in …, 2010 - Springer
M Rabinovitch
Membrane receptors, channels and transporters in pulmonary circulation, 2010•SpringerPeroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor that functions as
a transcription factor to regulate adipogenesis and metabolism by binding to PPAR
response elements (PPAREs) in the promoter region of various target genes. Activation of
PPARγ suppresses smooth muscle cell proliferation and migration. This chapter discusses
the potential protective role of PPARγ and its downstream signaling cascades in the
development of pulmonary arterial hypertension. Furthermore, the chapter also provides an …
a transcription factor to regulate adipogenesis and metabolism by binding to PPAR
response elements (PPAREs) in the promoter region of various target genes. Activation of
PPARγ suppresses smooth muscle cell proliferation and migration. This chapter discusses
the potential protective role of PPARγ and its downstream signaling cascades in the
development of pulmonary arterial hypertension. Furthermore, the chapter also provides an …
Abstract
Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor that functions as a transcription factor to regulate adipogenesis and metabolism by binding to PPAR response elements (PPAREs) in the promoter region of various target genes. Activation of PPARγ suppresses smooth muscle cell proliferation and migration. This chapter discusses the potential protective role of PPARγ and its downstream signaling cascades in the development of pulmonary arterial hypertension. Furthermore, the chapter also provides an overview on the cellular and molecular mechanisms involved in PPARγ-mediated inhibitory effect on pulmonary vascular remodeling, a major contributor to the elevated pulmonary vascular resistance in patients with pulmonary arterial hypertension.
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