[HTML][HTML] B cell sub-types following acute malaria and associations with clinical immunity

RT Sullivan, I Ssewanyana, S Wamala, F Nankya… - Malaria journal, 2016 - Springer
RT Sullivan, I Ssewanyana, S Wamala, F Nankya, P Jagannathan, JW Tappero…
Malaria journal, 2016Springer
Abstract Background Repeated exposure to Plasmodium falciparum is associated with
perturbations in B cell sub-set homeostasis, including expansion atypical memory B cells.
However, B cell perturbations immediately following acute malaria infection have been
poorly characterized, especially with regard to their relationship with immunity to malaria.
Methods To better understand the kinetics of B cell sub-sets following malaria, the
proportions of six B cell sub-sets were assessed at five time points following acute malaria in …
Background
Repeated exposure to Plasmodium falciparum is associated with perturbations in B cell sub-set homeostasis, including expansion atypical memory B cells. However, B cell perturbations immediately following acute malaria infection have been poorly characterized, especially with regard to their relationship with immunity to malaria.
Methods
To better understand the kinetics of B cell sub-sets following malaria, the proportions of six B cell sub-sets were assessed at five time points following acute malaria in four to 5 years old children living in a high transmission region of Uganda. B cell sub-set kinetics were compared with measures of clinical immunity to malaria—lower parasite density at the time of malaria diagnosis and recent asymptomatic parasitaemia.
Results
Atypical memory B cell and transitional B cell proportions increased following malaria. In contrast, plasmablast proportions were highest at the time of malaria diagnosis and rapidly declined following treatment. Increased proportions of atypical memory B cells were associated with greater immunity to malaria, whereas increased proportions of transitional B cells were associated with evidence of less immunity to malaria.
Conclusions
These findings highlight the dynamic changes in multiple B cell sub-sets following acute, uncomplicated malaria, and how these sub-sets are associated with developing immunity to malaria.
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