Improved methods for transplanting split-heart neonatal cardiac grafts into the ear pinna of mice and rats
TA Fey, RA Krause, GC Hsieh, JM Andrews… - … of pharmacological and …, 1998 - Elsevier
The rodent heterotopic ear–heart transplant method is a useful alternative to the more
technically demanding vascularized graft technique. We modified the procedure to improve
efficiency and used it in mice and rats to determine the survival times of both isologous and
allogeneic grafts and compare reference immunosuppressants. Bisected rat and mouse
cardiac (split-heart) isografts were uniformly viable up to 4 weeks postimplant; however, by
24 weeks only 90% of Lewis rat or C3H mouse split-heart isografts retained …
technically demanding vascularized graft technique. We modified the procedure to improve
efficiency and used it in mice and rats to determine the survival times of both isologous and
allogeneic grafts and compare reference immunosuppressants. Bisected rat and mouse
cardiac (split-heart) isografts were uniformly viable up to 4 weeks postimplant; however, by
24 weeks only 90% of Lewis rat or C3H mouse split-heart isografts retained …