[HTML][HTML] Subsets of macrophages and dendritic cells in nonobese diabetic mouse pancreatic inflammatory infiltrates: correlation with the development of diabetes
JGM Rosmalen, T Martin, C Dobbs, JSA Voerman… - Laboratory …, 2000 - Elsevier
Islet-specific T cells are essential in the development of type I diabetes. The role of non-
lymphoid cells is relatively unclear, although infiltration of dendritic cells and macrophages
is the first sign of islet autoimmunity in diabetes-prone nonobese diabetic (NOD) mice.
BDC2. 5 is one of the autoreactive T cell clones isolated from NOD mice. Transfer of BDC2.
5 T cells into young NOD mice accelerates diabetes development, whereas transgenic
expression of the BDC2. 5 T cell receptor on NOD T cells (BDC2. 5 TCR-Tg NOD) markedly …
lymphoid cells is relatively unclear, although infiltration of dendritic cells and macrophages
is the first sign of islet autoimmunity in diabetes-prone nonobese diabetic (NOD) mice.
BDC2. 5 is one of the autoreactive T cell clones isolated from NOD mice. Transfer of BDC2.
5 T cells into young NOD mice accelerates diabetes development, whereas transgenic
expression of the BDC2. 5 T cell receptor on NOD T cells (BDC2. 5 TCR-Tg NOD) markedly …