[HTML][HTML] 24-nor-ursodeoxycholic acid ameliorates inflammatory response and liver fibrosis in a murine model of hepatic schistosomiasis

M Sombetzki, CD Fuchs, P Fickert, CH Österreicher… - Journal of …, 2015 - Elsevier
Background & Aims Intrahepatic granuloma formation and fibrosis characterize the
pathological features of Schistosoma mansoni infection. Based on previously observed
substantial anti-fibrotic effects of 24-nor-ursodeoxycholic acid (norUDCA) in Abcb4/Mdr2−/−
mice with cholestatic liver injury and biliary fibrosis, we hypothesized that norUDCA
improves inflammation-driven liver fibrosis in S. mansoni infection. Methods Adult NMRI
mice were infected with 50 S. mansoni cercariae and after 12 weeks received either …