Resistance of rat hepatocytes against bile acid-induced apoptosis in cholestatic liver injury is due to nuclear factor-kappa B activation
MH Schoemaker, WM Gommans, LC de la Rosa… - Journal of …, 2003 - Elsevier
Background/Aims: To examine the extent and mechanisms of apoptosis in cholestatic liver
injury and to explore the role of the transcription factor nuclear factor-kappa B in protection
against bile acid-induced apoptosis. Methods: Cholestatic liver injury was induced by bile
duct ligation in Wistar rats. Furthermore, primary cultures of rat hepatocytes were exposed to
glycochenodeoxycholic acid (GCDCA), tauroursodeoxycholic acid (TUDCA),
taurochenodeoxycholic acid (TCDCA) and to cytokines. Apoptosis was determined by …
injury and to explore the role of the transcription factor nuclear factor-kappa B in protection
against bile acid-induced apoptosis. Methods: Cholestatic liver injury was induced by bile
duct ligation in Wistar rats. Furthermore, primary cultures of rat hepatocytes were exposed to
glycochenodeoxycholic acid (GCDCA), tauroursodeoxycholic acid (TUDCA),
taurochenodeoxycholic acid (TCDCA) and to cytokines. Apoptosis was determined by …