[HTML][HTML] Tumor necrosis factor α-dependent up-regulation of Lrh-1 and Mrp3 (Abcc3) reduces liver injury in obstructive cholestasis
Mrp3 (Abcc3) is markedly induced following bile duct ligation (BDL) in the rat and in some
human cholestatic liver diseases and is believed to ameliorate liver injury in this setting.
Recently, the orphan nuclear receptor fetoprotein transcription factor/cholesterol-7α-
hydroxylase promoter factor (CPF/FTF/Lrh-1) has been shown to activate Mrp3 expression.
However, whether inflammatory cytokines or elevated bile acid levels increased Lrh-1/Mrp3
expression in obstructive cholestasis was not known. We hypothesized that induction of …
human cholestatic liver diseases and is believed to ameliorate liver injury in this setting.
Recently, the orphan nuclear receptor fetoprotein transcription factor/cholesterol-7α-
hydroxylase promoter factor (CPF/FTF/Lrh-1) has been shown to activate Mrp3 expression.
However, whether inflammatory cytokines or elevated bile acid levels increased Lrh-1/Mrp3
expression in obstructive cholestasis was not known. We hypothesized that induction of …