The immune system is a complex network that acts to protect vertebrates from foreign
microorganisms and carries out immunosurveillance to combat cancer. In order to avoid
hyper-activation of the immune system leading to collateral damage tissues and organs and
to prevent self-attack, the network has the intrinsic control mechanisms that negatively
regulate immune responses. Central to this negative regulation are regulatory T (T-Reg)
cells, which through cytokine secretion and cell interaction limit uncontrolled clonal …