Inhibition of interleukin-6 trans-signaling prevents inflammation and endothelial barrier disruption in retinal endothelial cells
ML Valle, J Dworshak, A Sharma, AS Ibrahim… - Experimental eye …, 2019 - Elsevier
Vascular inflammation plays a critical role in the pathogenesis of diabetic retinopathy.
Recently, Interleukin-6 (IL-6) trans-signaling via soluble IL-6 receptor (sIL-6R) has emerged
as a prominent regulator of inflammation in endothelial cells. This study was designed to test
the hypothesis that selective inhibition of the IL-6 trans-signaling pathway will attenuate
inflammation and subsequent barrier disruption in retinal endothelial cells. Human retinal
endothelial cells (HRECs) were exposed to IL-6 and sIL-6R to induce IL-6 trans-signaling …
Recently, Interleukin-6 (IL-6) trans-signaling via soluble IL-6 receptor (sIL-6R) has emerged
as a prominent regulator of inflammation in endothelial cells. This study was designed to test
the hypothesis that selective inhibition of the IL-6 trans-signaling pathway will attenuate
inflammation and subsequent barrier disruption in retinal endothelial cells. Human retinal
endothelial cells (HRECs) were exposed to IL-6 and sIL-6R to induce IL-6 trans-signaling …