Epithelial autophagy controls chronic colitis by reducing TNF-induced apoptosis
J Pott, KJ Maloy - Autophagy, 2018 - Taylor & Francis
J Pott, KJ Maloy
Autophagy, 2018•Taylor & FrancisGenome-wide association studies (GWAS) linking polymorphisms in ATG16L1 with
susceptibility to inflammatory bowel disease (IBD) have prompted mucosal immunologists to
investigate the functional roles of macroautophagy/autophagy in different cell types in the
gut. Here we present a recent study that addressed 2 key questions: in which cell type is
autophagy deficiency most detrimental during chronic colitis and what is the functional role
of autophagy in those cells? We report that autophagy in intestinal epithelial cells (IECs) acts …
susceptibility to inflammatory bowel disease (IBD) have prompted mucosal immunologists to
investigate the functional roles of macroautophagy/autophagy in different cell types in the
gut. Here we present a recent study that addressed 2 key questions: in which cell type is
autophagy deficiency most detrimental during chronic colitis and what is the functional role
of autophagy in those cells? We report that autophagy in intestinal epithelial cells (IECs) acts …
Abstract
Genome-wide association studies (GWAS) linking polymorphisms in ATG16L1 with susceptibility to inflammatory bowel disease (IBD) have prompted mucosal immunologists to investigate the functional roles of macroautophagy/autophagy in different cell types in the gut. Here we present a recent study that addressed 2 key questions: in which cell type is autophagy deficiency most detrimental during chronic colitis and what is the functional role of autophagy in those cells? We report that autophagy in intestinal epithelial cells (IECs) acts to limit intestinal inflammation by protecting them from TNF-induced apoptosis and we discuss the potential implications for IBD treatment.
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