Lipocalin 2 drives neutrophilic inflammation in alcoholic liver disease
V Wieser, P Tymoszuk, TE Adolph, C Grander… - Journal of …, 2016 - Elsevier
Background & Aims Alcoholic steatohepatitis (ASH) is characterised by neutrophil infiltration
that contributes to hepatic injury and disease. Lipocalin-2 (LCN2) was originally identified as
siderophore binding peptide in neutrophils, which exerted tissue protective effects in several
disease models. Here we investigate the role of LCN2 in the pathogenesis of alcohol-
induced liver injury. Methods We compared hepatic LCN2 expression in ASH patients,
alcoholic cirrhosis patients without evidence of ASH and patients with non-alcoholic fatty …
that contributes to hepatic injury and disease. Lipocalin-2 (LCN2) was originally identified as
siderophore binding peptide in neutrophils, which exerted tissue protective effects in several
disease models. Here we investigate the role of LCN2 in the pathogenesis of alcohol-
induced liver injury. Methods We compared hepatic LCN2 expression in ASH patients,
alcoholic cirrhosis patients without evidence of ASH and patients with non-alcoholic fatty …