[HTML][HTML] Mycobacterium avium Infection Induces H-Ferritin Expression in Mouse Primary Macrophages by Activating Toll-Like Receptor 2

S Silva-Gomes, C Bouton, T Silva, P Santambrogio… - PloS one, 2013 - journals.plos.org
S Silva-Gomes, C Bouton, T Silva, P Santambrogio, P Rodrigues, R Appelberg, MS Gomes
PloS one, 2013journals.plos.org
Important for both host and pathogen survivals, iron is a key factor in determining the
outcome of an infectious process. Iron with-holding, including sequestration inside tissue
macrophages, is considered an important strategy to fight infection. However, for intra-
macrophagic pathogens, such as Mycobacterium avium, host defence may depend on
intracellular iron sequestration mechanisms. Ferritin, the major intracellular iron storage
protein, plays a critical role in this process. In the current study, we studied ferritin expression …
Important for both host and pathogen survivals, iron is a key factor in determining the outcome of an infectious process. Iron with-holding, including sequestration inside tissue macrophages, is considered an important strategy to fight infection. However, for intra-macrophagic pathogens, such as Mycobacterium avium, host defence may depend on intracellular iron sequestration mechanisms. Ferritin, the major intracellular iron storage protein, plays a critical role in this process. In the current study, we studied ferritin expression in mouse bone marrow-derived macrophages upon infection with M. avium. We found that H-ferritin is selectively increased in infected macrophages, through an up-regulation of gene transcription. This increase was mediated by the engagement of Toll like receptor-2, and was independent of TNF-alpha or nitric oxide production. The formation of H-rich ferritin proteins and the consequent iron sequestration may be an important part of the panoply of antimicrobial mechanisms of macrophages.
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