[HTML][HTML] A dynamic COVID-19 immune signature includes associations with poor prognosis

AG Laing, A Lorenc, I Del Molino Del Barrio, A Das… - Nature medicine, 2020 - nature.com
AG Laing, A Lorenc, I Del Molino Del Barrio, A Das, M Fish, L Monin, M Muņoz-Ruiz…
Nature medicine, 2020nature.com
Improved understanding and management of COVID-19, a potentially life-threatening
disease, could greatly reduce the threat posed by its etiologic agent, SARS-CoV-2. Toward
this end, we have identified a core peripheral blood immune signature across 63 hospital-
treated patients with COVID-19 who were otherwise highly heterogeneous. The signature
includes discrete changes in B and myelomonocytic cell composition, profoundly altered T
cell phenotypes, selective cytokine/chemokine upregulation and SARS-CoV-2-specific …
Abstract
Improved understanding and management of COVID-19, a potentially life-threatening disease, could greatly reduce the threat posed by its etiologic agent, SARS-CoV-2. Toward this end, we have identified a core peripheral blood immune signature across 63 hospital-treated patients with COVID-19 who were otherwise highly heterogeneous. The signature includes discrete changes in B and myelomonocytic cell composition, profoundly altered T cell phenotypes, selective cytokine/chemokine upregulation and SARS-CoV-2-specific antibodies. Some signature traits identify links with other settings of immunoprotection and immunopathology; others, including basophil and plasmacytoid dendritic cell depletion, correlate strongly with disease severity; while a third set of traits, including a triad of IP-10, interleukin-10 and interleukin-6, anticipate subsequent clinical progression. Hence, contingent upon independent validation in other COVID-19 cohorts, individual traits within this signature may collectively and individually guide treatment options; offer insights into COVID-19 pathogenesis; and aid early, risk-based patient stratification that is particularly beneficial in phasic diseases such as COVID-19.
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