[HTML][HTML] Acute humoral rejection of renal allografts in CCR5–/–recipients
A Bickerstaff, T Nozaki, JJ Wang, R Pelletier… - American Journal of …, 2008 - Elsevier
Increasing detection of acute humoral rejection (AHR) of renal allografts has generated the
need for appropriate animal models to investigate underlying mechanisms. Murine
recipients lacking the chemokine receptor CCR5 reject cardiac allografts with marked C3d
deposition in the parenchymal capillaries and high serum donor-reactive antibody titers,
features consistent with AHR. The rejection of MHC-mismatched renal allografts from A/J (H-
2 a) donors by B6. CCR5–/–(H-2 b) recipients was investigated. A/J renal allografts survived …
need for appropriate animal models to investigate underlying mechanisms. Murine
recipients lacking the chemokine receptor CCR5 reject cardiac allografts with marked C3d
deposition in the parenchymal capillaries and high serum donor-reactive antibody titers,
features consistent with AHR. The rejection of MHC-mismatched renal allografts from A/J (H-
2 a) donors by B6. CCR5–/–(H-2 b) recipients was investigated. A/J renal allografts survived …