Abstract Anti-myeloperoxidase (anti-MPO) antibodies have been implicated in the
pathogenesis of small-vessel vasculitis, but the molecular mechanisms by which these
antibodies contribute to disease are unknown. For determination of how anti-MPO
antibodies affect inflammatory cell recruitment in small-vessel vasculitis, intravital
microscopy was used to monitor leukocyte behavior in the accessible cremasteric
microvessels under various experimental conditions. After local pretreatment of the …