Evidence for systemic immune system alterations in sporadic amyotrophic lateral sclerosis (sALS)
R Zhang, R Gascon, RG Miller, DF Gelinas… - Journal of …, 2005 - Elsevier
Sporadic amyotrophic lateral sclerosis (sALS) is a progressive neuroinflammatory disease of
spinal cord motor neurons of unclear etiology. Blood from 38 patients with sALS, 28 aged-
match controls, and 25 Alzheimer's disease (AD) patients were evaluated and activated
monocyte/macrophages were observed in all patients with sALS and AD; the degree of
activation was directly related to the rate of sALS disease progression. Other parameters of T-
cell activation and immune globulin levels showed similar disease associated changes …
spinal cord motor neurons of unclear etiology. Blood from 38 patients with sALS, 28 aged-
match controls, and 25 Alzheimer's disease (AD) patients were evaluated and activated
monocyte/macrophages were observed in all patients with sALS and AD; the degree of
activation was directly related to the rate of sALS disease progression. Other parameters of T-
cell activation and immune globulin levels showed similar disease associated changes …