[HTML][HTML] GADD45a physically and functionally interacts with TET1
S Kienhöfer, MU Musheev, U Stapf, M Helm… - Differentiation, 2015 - Elsevier
DNA demethylation plays a central role during development and in adult physiology.
Different mechanisms of active DNA demethylation have been established. For example,
Growth Arrest and DNA Damage 45-(GADD45) and Ten-Eleven-Translocation (TET)
proteins act in active DNA demethylation but their functional relationship is unresolved. Here
we show that GADD45a physically interacts–and functionally cooperates with TET1 in
methylcytosine (mC) processing. In reporter demethylation GADD45a requires endogenous …
Different mechanisms of active DNA demethylation have been established. For example,
Growth Arrest and DNA Damage 45-(GADD45) and Ten-Eleven-Translocation (TET)
proteins act in active DNA demethylation but their functional relationship is unresolved. Here
we show that GADD45a physically interacts–and functionally cooperates with TET1 in
methylcytosine (mC) processing. In reporter demethylation GADD45a requires endogenous …