[HTML][HTML] MEKK4 stimulation of p38 and JNK activity is negatively regulated by GSK3β
AN Abell, DA Granger, GL Johnson - Journal of Biological Chemistry, 2007 - ASBMB
The MAPK kinase kinase MEKK4 is required for neurulation and skeletal patterning during
mouse development. MEKK4 phosphorylates and activates MKK4/MKK7 and MKK3/MKK6
leading to the activation of JNK and p38, respectively. MEKK4 is believed to be auto-
inhibited, and its interaction with other proteins controls its dimerization and activation.
TRAF4, GADD45, and Axin each bind and activate MEKK4, with TRAF4 and Axin binding to
the kinase domain and GADD45 binding within the N-terminal regulatory domain. Here we …
mouse development. MEKK4 phosphorylates and activates MKK4/MKK7 and MKK3/MKK6
leading to the activation of JNK and p38, respectively. MEKK4 is believed to be auto-
inhibited, and its interaction with other proteins controls its dimerization and activation.
TRAF4, GADD45, and Axin each bind and activate MEKK4, with TRAF4 and Axin binding to
the kinase domain and GADD45 binding within the N-terminal regulatory domain. Here we …