[HTML][HTML] Pixel-based image analysis of HSP70, GADD45 and MAP2 mRNA expression after focal cerebral ischemia: hemodynamic and histological correlates
R Schmidt-Kastner, W Zhao, J Truettner… - Molecular brain …, 1998 - Elsevier
Gene expression studies with in situ hybridization after focal brain ischemia indicate a
variety of distinct anatomical patterns. An important question is to what extent such reactive
gene expression correlates with neuronal damage or survival. To study these questions, we
focused on two stressed-induced genes, heat shock protein 70 (HSP70) and growth-arrest
and DNA damage-inducible gene (GADD) 45 mRNA, and we compared reactive changes in
mRNA to loss of the constitutive signal for microtubule-associated protein 2 (MAP2) mRNA …
variety of distinct anatomical patterns. An important question is to what extent such reactive
gene expression correlates with neuronal damage or survival. To study these questions, we
focused on two stressed-induced genes, heat shock protein 70 (HSP70) and growth-arrest
and DNA damage-inducible gene (GADD) 45 mRNA, and we compared reactive changes in
mRNA to loss of the constitutive signal for microtubule-associated protein 2 (MAP2) mRNA …