[HTML][HTML] Stress-induced skeletal muscle Gadd45a expression reprograms myonuclei and causes muscle atrophy
SM Ebert, MC Dyle, SD Kunkel, SA Bullard… - Journal of Biological …, 2012 - ASBMB
Diverse stresses including starvation and muscle disuse cause skeletal muscle atrophy.
However, the molecular mechanisms of muscle atrophy are complex and not well
understood. Here, we demonstrate that growth arrest and DNA damage-inducible 45a
protein (Gadd45a) is a critical mediator of muscle atrophy. We identified Gadd45a through
an unbiased search for potential downstream mediators of the stress-inducible, pro-atrophy
transcription factor ATF4. We show that Gadd45a is required for skeletal muscle atrophy …
However, the molecular mechanisms of muscle atrophy are complex and not well
understood. Here, we demonstrate that growth arrest and DNA damage-inducible 45a
protein (Gadd45a) is a critical mediator of muscle atrophy. We identified Gadd45a through
an unbiased search for potential downstream mediators of the stress-inducible, pro-atrophy
transcription factor ATF4. We show that Gadd45a is required for skeletal muscle atrophy …