TOX promotes the exhaustion of antitumor CD8+ T cells by preventing PD1 degradation in hepatocellular carcinoma
Background & Aims The thymocyte selection-associated high mobility group box protein
(TOX) plays a vital role in T cell development and differentiation, however, its role in T cell
exhaustion was unexplored. Here, we aim to investigate the role of TOX in regulating the
antitumor effect of CD8+ T cells in hepatocellular carcinoma. Methods Fully functional,
partially and severely exhausted tumor-infiltrating CD8+ T cells were sorted by flow
cytometry and subjected to transcriptome sequencing analysis. Upregulated TOX …
(TOX) plays a vital role in T cell development and differentiation, however, its role in T cell
exhaustion was unexplored. Here, we aim to investigate the role of TOX in regulating the
antitumor effect of CD8+ T cells in hepatocellular carcinoma. Methods Fully functional,
partially and severely exhausted tumor-infiltrating CD8+ T cells were sorted by flow
cytometry and subjected to transcriptome sequencing analysis. Upregulated TOX …